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Application of medicinal chemistry principles to the design and synthesis of subpopulation selective serotonergic and cholinergic ligands as pharmacological probes. Investigations of the pharmacological actions and mechanisms of action of drugs of abuse with emphasis on hallucinogens, stimulants, and designer drugs.
Recent publications:
222. Dowd,C. S.; Herrick-Davis, K.; Egan, C.; DuPre, A.; Teitler, M.; Glennon, R. A. 1-[4-(3-Phenylalkyl)phenyl]-2-aminopropanes as 5-HT2A partial agonists. J. Med. Chem 2000, 43, 3074-3084..
223. Glennon, R. A.; Young, R. MDMA stimulus generalization to the 5-HT1A serotonin agonist 8-OH DPAT. Pharmacol. Biochem. Behav. 2000, 66, 483-488.
224. Young, R.; Glennon, R. A. Stimulus effects of phenylpropanolamine optical isomers in (+)amphetamine-trained rats. Pharmacol. Biochem. Behav. 2000, 66, 489-494.
225. Dukat, M.; Young, R.; Darmani, N.; Ahmed, B.; Glennon, R. A. The 5-HT3 agent N-(3-chlorophenyl)guanidine (MD-354) serves as a discriminative stimulus in rats and displays partial agonist character in a shrew emesis assay. Psychopharmacology 2000, 150, 200-207.
226. Hellberg, M.; Stubbins, J. F.; Glennon, R. A. A preliminary investigation of mesoionic xanthine analogs as inhibitors of platelet aggregation. Bioorg. Med. Chem. Lett.,2000, 8, 1917-1923.
227. Ablordeppey, S. Y.; Fischer, J. B.; Glennon, R. A. Is a nitrogen atom an important pharmacophoric element in sigma ligand binding? Bioorg. Med. Chem.,2000, 8, 2105-2111.
228. Tsai, Y.; Dukat, M.; Slassi, M.; MacLean, N.; Demchyshyn, L.; Savage, J. E.; Roth, B. L.; Hufesein, S.; Glennon, R. A. N1-Benzenesulfonamidotryptamines as novel 5-HT6 antagonists. Bioorg. Med. Chem. Lett., 2000, 10, 2295-2299.
229. Ferretti, G.; Dukat, M.; Giannella, M.; Piergentili, A.; Pigini, M.; Quaglia, W.; Damaj, M. I.; Martin, B. R.; Glennon, R. A. Chain-lengthened and imidazoline analogs of nicotine. Bioorg. Med. Chem. Lett 2000, 10, 2665-2668.
230. Lee, M.; Rangisetty, J. B.; Dukat, M.; Slassi, A.; Maclean, N.; Lee, D. K. H.; Glennon, R. A. 5-HT6 Serotonin receptor binding affinities of N1-benzenesulfonyl and related tryptamines. Med. Chem. Res. 2000, 10, 230-242.
231. Prisinzanao, T; Law, H.; Dukat, M.; Slassi, A.; Maclean, N.; Demchyshyn, L.; Glennon, R. A. Imidazoline-modified benzylimidazolines as h5-HT1D/1B serotonergic ligands. Bioorg. Med. Chem 2001, 9, 613-619.
232. Westkaemper, R. B.; Runyon, S. P.; Savage, J. E.; Roth, B. L.; Glennon, R. A. Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogs at the 5-HT2A serotonin receptor. Bioorg. Med. Chem. Lett 2001, 11, 563-566.
233. Runyon, S. P.; Savage, J. E.; Taroua, M.; Roth, B. L.; Glennon, R. A.; Westkaemper, R. B. Influence of chain length and N-alkylation on the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene. Bioorg. Med. Chem. Lett 2001, 11, 655-658.
234. Prisinzano, T. P.; Law, H.; Slassi, A.; MaClean, N.; Demchyshyn, L.; Glennon, R. A. QSAR studies on 2-benzyl-imidazoline analogs as h5-HT1D/1B serotonin receptor ligands. Med. Chem. Res. 2001, 10, 309-317.
235. Rangisetty, J. B.; Bondarev, M. L.; Chang-Fong, J.; Young, R.; Glennon, R. A. PMMA-Stimulus generalization to the optical isomers of MBDB and 3,4-DMA. Pharmacol. Biochem. Behav. 2001, 69, 261-267.
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