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The Hackett laboratory is involved in the application of computational quantum chemistry and molecular dynamics simulation, complemented by classic biological chemistry, to solve problems in enzymology, reactive intermediate chemistry, and drug discovery. The primary focus of the laboratory is cytochrome P450 (CYP) enzymology, with particular emphasis on P450 enzymes that have been identified as targets for therapeutic intervention.
Publications:
Wang, J.; Kubicki, J.; Burdzinski, G.; Hackett, J. C.; Gustafson, T. L.; Hadad, C. M.; Platz, M. S. Early events in the photochemistry of 2-naphthyl azide from femtosecond UV/Vis spectroscopy and quantum chemical calculations. Direct Observation of a very short-lived singlet nitrene. J. Org. Chem. Accepted for publication, In press.
Hackett, J. C; Sanan, T.; Hadad, C. M. Oxidation of perhalogenated benzenes by cytochrome P450 Compound I. Biochemistry, 2007, 46, 5924-5940.
Muthukrishnan, S.; Mandel, S. M.; Hackett, J. C.; Singh, N. D. P.; Hadad, C. M.; Gudmundsdottir, A. D. Competition between a-cleavage and energy transfer in a-azidoacetophenones. J. Org. Chem. 2007, 72, 2757-2768.
Burdzinski, G.; Hackett, J. C.; Wang, J.; Gustafson, T.; Hadad, C. M.; Platz, M. S. Early Events in the Photochemistry of Aryl Azides from Femtosecond UV/Vis Spectroscopy and Quantum Chemical Calculations. J. Am. Chem. Soc. 2006, 128, 13402-13411.
Su, B.; Hackett, J. C ; Diaz-Cruz, E. S.; Kim, Y.-W.; Brueggemeier, R. W. Lead optimization of 7-benzyloxy 2-(4’-pyridylmethyl)thio isoflavone aromatase inhibitors. Bioorg. Med. Chem. 2005, 13, 6571-6577.
Burdzinski, G.; Gustafson, T.; Hackett, J. C; Hadad, C. M.; Platz, M. S. The Direct Detection of an Aryl Azide Excited State: An Ultrafast Study of the Photochemistry of Para and Ortho-Biphenyl Azide. J. Am. Chem. Soc. 2005, 127, 13764-13765.
Brueggemeier, R. W.; Hackett, J. C; Diaz-Cruz, E. D. Aromatase inhibitors for the treatment of breast cancer. Endocrine Rev. 2005, 26, 331-345.
Hackett, J. C; Brueggemeier, R. W.; Hadad, C. M. The final catalytic step of cytochrome P450 aromatase: A density functional theory study. J. Am. Chem. Soc. 2005, 127, 5224-5237.
Hackett, J. C; Kim, Y.-W.; Brueggemeier, R. W. Synthesis and Characterization of Azole Isoflavone Inhibitors of Aromatase. Bioorg. Med. Chem. 2005, 13, 4063-4070.
Kim, Y.-W.; Hackett, J. C; Brueggemeier, R. W. Synthesis and Aromatase Inhibitory Activity of Novel Pyridine-Containing Isoflavones. J. Med. Chem. 2004, 47, 4032-4040
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